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Biochemical association between essential trace elements and susceptibility to Leishmania major in BALB/c and C57BL/6 mice BJID
Amini,Marzyeh; Nahrevanian,Hossein; Khatami,Shohreh; Farahmand,Mahin; Mirkhani,Fatemeh; Javadian,Seifoddin.
Several enzymes that contribute to immune system responses require zinc and copper as trace elements for their activity. We examined zinc and copper levels in two susceptible Balb/c mouse lines and resistant C57bl/6 mice infected with Leishmania major MRHO/IR/75/ER, a prevalent strain that causes cutaneous leishmaniasis in Iran. Serum Zn and Cu were determined by flame atomic absorption spectrophotometry. Higher Cu levels were found in infected C57bl/6 mice and higher Zn levels were found in infected Balb/c mice. Also, Cu/Zn ratios were increased in both the Balb/c and the C57bl/6 mice. We conclude that concentrations of essential trace elements vary during cutaneous leishmaniasis infection and that this variation is associated with...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Balb/c; C57bl/6; CL; Iran; Leishmania major; Treatment; Cu; Zn.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200002
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